ea0089b6 | Basic Science | NANETS2022
Guenter Rachael
, Ducharme Maxwell
, Herring Brendon
, Montes Odalyz
, McCaw Tyler
, Lee Goo
, Dhall Deepti
, MacVicar Caroline
, Chen Herbert
, Lapi Suzanne E.
, Larimer Benjamin
, Bart Rose J.
Background: Current theragnostic techniques for pancreatic neuroendocrine tumors (pNETs) exploit the overexpression of somatostatin receptors (SSTRs) on the cell surface. However, approximately 25% of low-grade and most high-grade pNETs do not express SSTRs, requiring alternative theranostics. Calreticulin (CALR) is a protein linked to reticular calcium homeostasis and immunogenic cell death. Upon sufficient cellular insult, CALR translocates from the endoplasmic reticulum (ER...